Cancer risk in mutation carriers of DNA-mismatch-repair genes

Cancer risks after endometrial cancer in mismatch repair mutation carriers.

Recent years have seen increasing attention to the management of endometrial cancer risk in families with hereditary nonpolyposis colorectal cancer or Lynch syndrome (HNPCC/LS). Nevertheless, because endometrial cancer is less common and carries a lower mortality (1) than colorectal cancer in mismatch repair gene (MMR) mutation carriers, it may be an afterthought for many providers and patients...

Identification and survival of carriers of mutations in DNA mismatch-repair genes in colon cancer.

BACKGROUND The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease. METHODS Without preselection and regardless of family history, we recruited 870 patients under the age of 55 years soon after they received a diagnosis of colorectal cancer. We studied these patients for germ-line mutati...

DNA mismatch repair genes and colorectal cancer.

Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers.

OBJECTIVE To investigate the association of body mass index (BMI) in early adulthood and endometrial cancer risk for carriers of a germline mutation in a DNA mismatch repair gene. METHODS We estimated the association between BMI at age 18-20 years and endometrial cancer risk for mismatch repair gene mutation carriers and, as a comparison group, noncarriers using 601 female carriers of a germl...

Metachronous colorectal cancer risk for mismatch repair gene mutation carriers – the advantage of more extensive surgery

BACKGROUND Surgical management of colon cancer for patients with Lynch syndrome who carry a mismatch repair (MMR) gene mutation is controversial. The decision to remove more or less of the colon involves the consideration of a relatively high risk of metachronous colorectal cancer (CRC) with the impact of more extensive surgery. OBJECTIVE To estimate and compare the risks of metachronous CRC ...